Global Update: GlaxoSmithKline Tops Access to Medicines Index


Sang Tan/Associated Press







GlaxoSmithKline hung on to its perennial top spot in the new Access to Medicines Index released last week, but its competitors are closing in.


Every two years, the index ranks the world’s top 20 pharmaceutical companies based on how readily they get medicines they hold patents on to the world’s poor, how much research they do on tropical diseases, how ethically they conduct clinical trials in poor countries, and similar issues.


Johnson & Johnson shot up to second place, while AstraZeneca fell to 16th from 7th. AstraZeneca has had major management shake-ups. It did not do less, but the industry is improving so rapidly that others outscored it, the report said.


The index was greeted with skepticism by some drugmakers when it was introduced in 2008. But now 19 of the 20 companies have a board member or subcommittee tracking how well they do at what the index measures, said David Sampson, the chief author.


The one exception was a Japanese company. As before, Japanese drugmakers ranked at or near the index’s bottom, and European companies clustered near the top. Generic companies — most of them Indian — that export to poor countries are ranked separately.


Johnson & Johnson moved up because it created an access team, disclosed more and bought Crucell, a vaccine company.


The foundation that creates the index now has enough money to continue for five more years, said its founder, Wim Leereveld, a former pharmaceutical executive.


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U.S. auto sales zoom in the wake of Superstorm Sandy









With the presidential election and Superstorm Sandy behind them, car shoppers headed for dealer lots last month in the biggest numbers since early 2008.


Multiple brands, including Honda, Nissan, Hyundai and BMW, had their best Novembers ever last month. The import nameplates generally reported stronger gains than the domestic brands, helped by new products such as the new-generation Honda Accord and a new Nissan Pathfinder sport utility vehicle.


Automakers sold more than 1.1 million vehicles last month, a 15% gain over November 2011. Bolstered by shoppers replacing some of the 250,000 vehicles estimated to have been destroyed by Sandy, that translated into a seasonally adjusted annual rate of about 15.5 million, the highest since January 2008, according to industry research firm Autodata Corp.





Consumers leaned toward fuel-efficient cars and small SUVs. With gas prices around $3.50 a gallon in much of the nation, and even higher in car-crazy California, sales of hybrid vehicles also appear to be taking off.


Led by its hot-selling Prius line of hybrids, Toyota Motor Corp. posted November hybrid vehicle sales of 24,682 in the U.S., a 29% increase over the same month last year.


But for the first time since it started selling hybrids in the U.S. in 2000, Toyota has serious competition in the hybrid market.


Ford Motor Co. said it sold nearly 5,000 of its new C-Max hybrid in November, up about 50% from the car's first full month of sales in October. Combined with its other offerings, the automaker sold about 6,500 hybrids in November, its best month ever for those vehicles, which use both gas and electric motors to increase fuel efficiency.


Ford has sold 9,000 of the C-Max models since they first went on sale a little more than two months ago. That amounts to about a quarter of the hybrid volume the automaker sold in all of 2011 and underscores how important the vehicle is to Ford's hybrid strategy. If C-Max sales keep on pace, the automaker will easily double its hybrid sales in the current model year.


Certainly hybrids are starting to catch on with consumers. Sales of hybrids by Toyota and Ford and General Motors Co.'s Chevrolet Volt — technically a plug-in hybrid that runs on gasoline once its electric battery charge runs out — were nearly 35,000 last month, up about 40% from November 2011.


Sales of hybrids and plug-in electric cars are expected to top 500,000 in the U.S. for the first time both in this calendar year and in the 2013 model year, said Alan Baum of the Baum & Associates research firm. That would be about 3.5% of the U.S. auto market.


One buyer is Kate Ochsman, a West Hollywood actress who recently purchased a white C-Max. Ochsman said she now spends about $50 to fill up the Ford every two weeks instead of the $80 a week she spent to gas up a BMW X5 SUV with a V-8 engine.


"I really like it," Ochsman said. The car is "great getting around anywhere in L.A., and it is almost eerily quiet. It has a lot of bells and whistles, but it does drive like a hybrid. It doesn't have the power my BMW had."


About a quarter of Ford's C-Max sales are in California, a market dominated by Toyota, especially in the hybrid market.


"That's strategically important to Ford, because California is a market where our share has been traditionally lower," said C.J. O'Donnell, the automaker's electrified-vehicle marketing manager. "The No. 1 trade-in is a Prius, followed by some of the Honda products."


In its marketing efforts, Ford is pitching the C-Max as a head-to-head competitor with the Prius V, a small station wagon. Toyota sold about 2,700 of the Prius V last month, about 2,300 fewer than Ford's C-Max sales.


Toyota has responded by pointing out that the C-Max is closer in size to the smaller Prius hatchback model, yet gets about 6% poorer fuel economy and has a base price about 15% higher.


"The Prius V has more versatility and cargo space than C-Max," said Bill Fay, general manager of the automaker's Toyota division in the U.S.


Overall, Toyota's November sales rose to 161,695 vehicles, up 17.2% from the same month last year. Ford sales rose 6.4% to 177,092 vehicles.


General Motors Co. reported its highest November U.S. sales volume since 2007, with deliveries up 3.4% from a year earlier to 186,505 vehicles. Chrysler Group sales rose 14.4% to 122,565 units, its best November since 2007.


Volkswagen Group sales — including Audi — rose 28.2%, to 49,062 vehicles. It was the VW brand's best November since 1973.


American Honda Motor Co. sales jumped 38.9% in November, reaching 116,580 vehicles, an all-time record for the month.


"We are now surpassing sales records set pre-recession, a true sign that our business has recovered," said John Mendel, executive vice president of sales at American Honda.


Nissan North America reported record November U.S. sales of 96,197 vehicles, up 12.9%.


Hyundai Motor America also posted a record November, with U.S. sales up 7.8% to 53,487 vehicles.


And BMW reported its best U.S. sales month ever, with November sales of 31,213, an increase of 45% from a year earlier.


Whether the industry can continue to sell at this pace depends largely on the federal budget negotiations underway between Congress and the Obama administration, executives at several automakers said Monday.


"Exactly how much growth we can expect next year will depend in part on how Congress and the president resolve the 'fiscal cliff' issue. We are certainly not going to prescribe policy fixes," said Kurt McNeil, GM's vice president of U.S. sales operations. "But I will say that markets and consumers hate the uncertainty."


jerry.hirsch@latimes.com





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Kern County farmers take on oil industry, California









SHAFTER — In this lush pocket of Kern County, where the agriculture and oil industries have long coexisted, Mike Hopkins' almond orchard has become a battlefield in a dispute that extends to the governor's office.


Hopkins is standing up to the oil industry — and Gov. Jerry Brown — by filing a lawsuit against the state to bar energy company Venoco Inc. from drilling an exploratory well on his farm without a full environmental review. Venoco has the mineral rights to Hopkins' 38-acre farm.


Across Kern County, other farmers are waging similar fights. With oil prices booming and energy companies eager to develop new wells, the state has granted oil companies permission to drill on farms without first assessing possible harm to the environment, as called for under the California Environmental Quality Act.





"I want the oil industry to make money," Hopkins said. But not if the drilling damages his farm and livelihood.


The exemptions from CEQA are precisely what Brown sought late in 2011 when he replaced two top officials in the state Conservation Department with appointees who agreed to ease environmental restrictions on energy companies.


In the months afterward, the department granted oil companies 19 exemptions statewide — a six-fold increase from the year before — and 14 energy firms gave more than $1.1 million to the governor's tax initiative, Proposition 30, which voters approved in November.


"I've never seen a CEQA exemption I didn't like," Brown told reporters at a news conference earlier this year.


In Kern, farmers pushed back after the state granted 16 exemptions in California's richest oil county. Four farmers wrote a letter to the state accusing officials of skirting the law by granting environmental waivers. The letter, sent in August by Irvine lawyer Gregory Sanders, asked regulators to explain "an institutional pattern and practice … in which the requirements of CEQA are disregarded" when considering oil permits.


"It doesn't take a rocket scientist to figure out what could go wrong with an oil well," Sanders said in an interview.


State officials and the governor's office declined to respond to questions for this story. But in a written statement to The Times, the Conservation Department's Division of Oil, Gas and Geothermal Resources defended the general use of exemptions.


The statement said oil projects are evaluated case by case, taking into consideration several factors, including proximity to residential communities and whether sites are in existing oil fields.


Nearly all of the state's exemptions cite the same CEQA provision: The operation would result in only a "minor alteration to land."


Environmental groups challenge that interpretation. They note that the provision is typically applied to small projects. The law gives such examples as painting bicycle lanes on a street, clearing flammable vegetation around a home and hosting a carnival in a parking lot.


"It's difficult for us to see how the exemption would ever apply to a new oil and gas well," said George Torgun, an attorney with Earthjustice, one of several environmental groups that have filed lawsuits against the state.


The energy industry contends the exemptions are needed to avoid lengthy delays, helping the economy in the process.


State data shows that the drive for oil is helping Kern County's recovery. The county is just 3,400 jobs short of matching its peak employment of 239,600, reached in 2007 at the height of the housing boom.


Emails obtained by The Times through a Public Records Act request show that before Brown fired the two Conservation Department officials, oil lobbyists had pushed regulators for exemptions — and appealed to higher-ranking state officials when the requests were denied.


In one case, Elena Miller, the Conservation Department's oil and gas supervisor, complained to her boss that AERA Energy had cleared land for well construction and built roads before doing a CEQA study.


"We can presume that little critters lived in that vegetation," she wrote. "This is their environmental program, tear it up, build a road, and then hire a (CEQA) consultant."


Brown fired Miller, saying she and others had needlessly slowed the permit process.





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Euro zone crisis drags down European ad spending: report












LONDON (Reuters) – The euro zone crisis has left Western Europe the only world region to see a fall in advertising spending this year, market research group ZenithOptimedia said.


The forecasting group said advertising expenditure in Western Europe fell 2.2 percent to $ 106.8 billion this year compared with an average increase of 3.3 percent worldwide.












North American ad spending rose 4.1 percent to $ 171.9 billion and Asia’s expenditure was up 6.1 percent to $ 140.1 billion this year.


“Developing markets, social media and online video are all growing rapidly, supporting continued expansion in global ad expenditure despite stagnation in the eurozone,” said Steve King, global chief executive of ZenithOptimedia Group.


The company, part of advertising agency Publicis, also said European ad spending would be flat next year before growing by about 2 percent in 2014 and 2015.


This leaves Europe lagging faster-growing regions such North America, which will grow by 3.5 percent next year, as well as Asia (5.5 percent) and Latin America (10 percent).


“The euro zone crisis is dragging down economic growth at the moment,” ZenithOptimedia said on Monday.


“Because the eurozone is in recession, its imports from other countries are slowing down or shrinking, and the risk of eurozone collapse adds to global uncertainty, leading companies to hoard cash instead of investing in growth,” the firm said in an emailed statement.


Ad spending generally tracks economic growth, so recessions tend to hit the shares of advertising agencies, including market leaders WPP, Omnicom, Interpublic Group and Publicis.


ZenithOptimedia said global ad expenditure would rise 4.1 percent next year to reach $ 518 billion, driven largely by faster growth in the developing markets.


(Editing by Helen Massy-Beresford)


Internet News Headlines – Yahoo! News


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Young down by boardwalk for benefit show

NEW YORK (AP) — Neil Young said Sunday that he couldn't see performing in the area devastated by Superstorm Sandy without doing something to help people who were affected by it.

Young and his longtime backing band, Crazy Horse, will hold a benefit concert for the American Red Cross' storm relief effort Thursday at the Borgata Hotel Casino & Spa in Atlantic City. The New Jersey coastline areas were hit hard by the storm in late October.

People in the New York area who suffered damage in the storm have been supporting him for 40 years, he said.

"I couldn't see coming back here and just playing and have it be business as usual," he said. Young is touring in the area, with concerts scheduled for Monday in Brooklyn and Tuesday in Bridgeport, Conn.

Minimum ticket prices for the standing-room show in Atlantic City will be $75 and $150, although Young notes there's no maximum. He hopes to raise several hundred thousand dollars for the Red Cross.

Young said he was invited to join the Dec. 12 benefit at New York's Madison Square Garden that will feature Bruce Springsteen, Paul McCartney, the Who, Kanye West and others, but had other obligations. Besides, there's enough star power there, he said.

"It wasn't going to make much difference whether I was there or not, so I decided to go someplace where I could make a difference," he said.

Young performed at a televised benefit in 2001 following the Sept. 11 terrorist attacks, memorably covering John Lennon's "Imagine."

Fans can expect a two-hour plus rock show on Thursday with opening band Everest. No special guests are planned, although Young issued an invitation to "anyone who wants to come in and play with us that we know and we know can play."

It's hard to resist wondering whether Young's epic "Like a Hurricane" will make it onto the set list, given the occasion.

"Anything's possible," Young said. "We have the equipment."

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Unboxed: Stand-Up Desks Gaining Favor in the Workplace





THE health studies that conclude that people should sit less, and get up and move around more, have always struck me as fitting into the “well, duh” category.




But a closer look at the accumulating research on sitting reveals something more intriguing, and disturbing: the health hazards of sitting for long stretches are significant even for people who are quite active when they’re not sitting down. That point was reiterated recently in two studies, published in The British Journal of Sports Medicine and in Diabetologia, a journal of the European Association for the Study of Diabetes.


Suppose you stick to a five-times-a-week gym regimen, as I do, and have put in a lifetime of hard cardio exercise, and have a resting heart rate that’s a significant fraction below the norm. That doesn’t inoculate you, apparently, from the perils of sitting.


The research comes more from observing the health results of people’s behavior than from discovering the biological and genetic triggers that may be associated with extended sitting. Still, scientists have determined that after an hour or more of sitting, the production of enzymes that burn fat in the body declines by as much as 90 percent. Extended sitting, they add, slows the body’s metabolism of glucose and lowers the levels of good (HDL) cholesterol in the blood. Those are risk factors toward developing heart disease and Type 2 diabetes.


“The science is still evolving, but we believe that sitting is harmful in itself,” says Dr. Toni Yancey, a professor of health services at the University of California, Los Angeles.


Yet many of us still spend long hours each day sitting in front of a computer.


The good news is that when creative capitalism is working as it should, problems open the door to opportunity. New knowledge spreads, attitudes shift, consumer demand emerges and companies and entrepreneurs develop new products. That process is under way, addressing what might be called the sitting crisis. The results have been workstations that allow modern information workers to stand, even walk, while toiling at a keyboard.


Dr. Yancey goes further. She has a treadmill desk in the office and works on her recumbent bike at home.


If there is a movement toward ergonomic diversity and upright work in the information age, it will also be a return to the past. Today, the diligent worker tends to be defined as a person who puts in long hours crouched in front of a screen. But in the 19th and early 20th centuries, office workers, like clerks, accountants and managers, mostly stood. Sitting was slacking. And if you stand at work today, you join a distinguished lineage — Leonardo da Vinci, Ben Franklin, Winston Churchill, Vladimir Nabokov and, according to a recent profile in The New York Times, Philip Roth.


DR. JAMES A. LEVINE of the Mayo Clinic is a leading researcher in the field of inactivity studies. When he began his research 15 years ago, he says, it was seen as a novelty.


“But it’s totally mainstream now,” he says. “There’s been an explosion of research in this area, because the health care cost implications are so enormous.”


Steelcase, the big maker of office furniture, has seen a similar trend in the emerging marketplace for adjustable workstations, which allow workers to sit or stand during the day, and for workstations with a treadmill underneath for walking. (Its treadmill model was inspired by Dr. Levine, who built his own and shared his research with Steelcase.)


The company offered its first models of height-adjustable desks in 2004. In the last five years, sales of its lines of adjustable desks and the treadmill desk have surged fivefold, to more than $40 million. Its models for stand-up work range from about $1,600 to more than $4,000 for a desk that includes an actual treadmill. Corporate customers include Chevron, Intel, Allstate, Boeing, Apple and Google.


“It started out very small, but it’s not a niche market anymore,” says Allan Smith, vice president for product marketing at Steelcase.


The Steelcase offerings are the Mercedes-Benzes and Cadillacs of upright workstations, but there are plenty of Chevys as well, especially from small, entrepreneurial companies.


In 2009, Daniel Sharkey was laid off as a plant manager of a tool-and-die factory, after nearly 30 years with the company. A garage tinkerer, Mr. Sharkey had designed his own adjustable desk for standing. On a whim, he called it the kangaroo desk, because “it holds things, and goes up and down.” He says that when he lost his job, his wife, Kathy, told him, “People think that kangaroo thing is pretty neat.”


Today, Mr. Sharkey’s company, Ergo Desktop, employs 16 people at its 8,000-square-foot assembly factory in Celina, Ohio. Sales of its several models, priced from $260 to $600, have quadrupled in the last year, and it now ships tens of thousands of workstations a year.


Steve Bordley of Scottsdale, Ariz., also designed a solution for himself that became a full-time business. After a leg injury left him unable to run, he gained weight. So he fixed up a desktop that could be mounted on a treadmill he already owned. He walked slowly on the treadmill while making phone calls and working on a computer. In six weeks, Mr. Bordley says, he lost 25 pounds and his nagging back pain vanished.


He quit the commercial real estate business and founded TrekDesk in 2007. He began shipping his desk the next year. (The treadmill must be supplied by the user.) Sales have grown tenfold from 2008, with several thousand of the desks, priced at $479, now sold annually.


“It’s gone from being treated as a laughingstock to a product that many people find genuinely interesting,” Mr. Bordley says.


There is also a growing collection of do-it-yourself solutions for stand-up work. Many are posted on Web sites like howtogeek.com, and freely shared like recipes. For example, Colin Nederkoorn, chief executive of an e-mail marketing start-up, Customer.io, has posted one such design on his blog. Such setups can cost as little as $30 or even less, if cobbled together with available materials.


UPRIGHT workstations were hailed recently by no less a trend spotter of modern work habits and gadgetry than Wired magazine. In its October issue, it chose “Get a Standing Desk” as one of its “18 Data-Driven Ways to Be Happier, Healthier and Even a Little Smarter.”


The magazine has kept tabs on the evolving standing-desk research and marketplace, and several staff members have become converts themselves in the last few months.


“And we’re all universally happy about it,” Thomas Goetz, Wired’s executive editor, wrote in an e-mail — sent from his new standing desk.


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Chinatrust Bank headquarters coming to downtown Los Angeles








Chinatrust Bank has agreed to move its U.S. headquarters from Torrance to downtown Los Angeles.

The bank will rent two floors in 801 Tower, a company representative said. The high-rise is in the financial district north of Staples Center.

“We wanted to be in a major financial area,” said Brian Gregson, head of Chinatrust U.S.A.’s retail banking group. “This is the early stage of getting our ducks in a row to start some expansion.”

The bank’s name will be affixed on top of the 25-story tower at 801 S. Figueroa St., he said.

Taiwan-based Chinatrust has 12 branches in the United States, seven of which are in Southern California. The bank will move about 175 employees to the new headquarters by the middle of next year, Gregson said.

Terms of the lease with landlord Mani Brothers Real Estate Group were not disclosed, but data provider CoStar said the agreement is for 10 years. At current rents, the lease for nearly 40,000 square feet would be valued at nearly $20 million.

Chinabank’s decision to move downtown is part of a recent trend for businesses to relocate their main offices to the financial center, reversing the exodus of previous decades, real estate broker Ted Simpson of Cushman & Wakefield said.

“This speaks to the emergence of downtown L.A. as a corporate headquarters destination not seen since the 1980s,” said Simpson, who represented the bank in the transaction with his partner Michael Ma.

Other companies to recently move their main offices or regional headquarters downtown include law firm Haight Brown Bonesteel and architecture firm Gensler.

“Corporations are once again choosing downtown for its attractiveness to its employees, not just low cost,” Simpson said.

Average rents are cheaper downtown than on the popular Westside, in part because downtown has higher vacancy. Large corporations including Arco and First Interstate Bank left downtown in past decades or substantially reduced their offices.


ALSO:


University Gateway student housing complex near USC sold

Artist Paul McCarthy will move operations to Eastside building


State Bar property sale opens door for downtown apartments






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Boy Scouts' opposition to background checks let pedophiles in









Amid reports of widespread sexual abuse of children in the late 1980s, several leading youth organizations began conducting criminal background checks of volunteers and staff members.


Big Brothers Big Sisters ordered the checks for all volunteers starting in 1986. Boys and Girls Clubs of America recommended their use the same year.


One of the nation's oldest and largest youth groups, however, was opposed — the Boy Scouts of America.





FULL COVERAGE: Inside the Boy Scouts' "perversion files"


Scouting officials argued that background checks would cost too much, scare away volunteers and provide a false sense of security. They successfully lobbied to kill state legislation that would have mandated FBI fingerprint screening.


While touting their efforts to protect children, the Scouts for years resisted one of the most basic tools for preventing abuse. The result: The organization let in hundreds of men with criminal histories of child molestation, many of whom went on to abuse more children, according to a Times analysis of the Scouts' confidential abuse files.


Scouting did not require criminal background checks for all volunteers until 2008 — despite calls from parents and staff who said its vetting system didn't work.


In 1989, a Scout committee chairman in St. Paul, Minn., decried the organization's "half-hearted" screening in a letter to headquarters.


"BSA is only creating an illusion of performing what they claim," K. Russell Sias wrote to Scout Chief Executive Ben Love. "It becomes quite clear that BSA is more concerned in 'passing the buck' than in accepting responsibility for those who are its adult leaders."


That same year, a Las Vegas scoutmaster with a criminal history of exposing himself to boys was arrested for sexually abusing a 12-year-old Scout. One parent said casinos did a better job of screening workers.


"The black eye which scouting has suffered in this … could easily have been avoided if the council had taken the simple expedient of doing a background investigation," the parent wrote to Scouting officials.


From 1985 to 1991 — when the detailed files obtained by The Times end — the Boy Scouts admitted more than 230 men with previous arrests or convictions for sex crimes against children, the analysis found.


The men were accused of molesting nearly 400 boys while in Scouting. They accounted for one in six of those expelled for alleged abuse during those years.


Scouting officials declined to be interviewed but said in a prepared statement that they have enhanced their policies over the years and tried "to ensure we are in line with and, where possible, ahead of society's knowledge of abuse and best practices for prevention."


"Numerous independent experts have recognized that our programs for protecting Scouts from abuse are among the best in the youth-serving community," it said.


The Scouts' past handling of child sexual abuse has come under increased scrutiny since October, after the court-ordered release of hundreds of confidential files dating back decades. The Times earlier obtained and analyzed a larger and more recent set of files — about 1,900 dossiers opened from 1970 to 1991.


The records, dubbed the "perversion files" by Scouting officials, have been a key tool for nearly a century, intended to keep out men expelled for alleged abuse.


The files also offer a detailed record of the system's failures. The Times reported in August that from 1970 to 1991 dozens of men previously expelled had slipped back into the program, only to be accused of molesting again. The Times later reported that Scouting officials failed to report hundreds of alleged abusers to police and often hid the allegations from parents and the public.


The organization has fought in court to prevent the release of more recent files, making it impossible to determine how many men with criminal histories were caught in the organization after 1991.


Court records and news accounts, however, show that convicted molesters continued to find new victims in Scouting.





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Ricky Martin finds new home on small screen

NEW YORK (AP) — Ricky Martin is saying goodbye to Broadway's "Evita." But don't cry for him.

The Latin superstar has a slew of new projects in the works, including two television series and a children's book.

"It's about growing," said Martin in an interview Friday. "It's a moment in my life where I just need to absorb and be surrounded by amazing actors and musicians and grow as an entertainer. I think this is going to be an amazing year for that."

Martin takes his final bow in the Andrew Lloyd Webber revival on Jan. 26. Then he heads down under to join the second season of the Australian edition of "The Voice." But the Grammy winner says not to expect any biting, Simon Cowellesque critiques.

"I don't believe in tough love. I believe in love, and I believe in being nurturing to new talented men and women," he said at an M.A.C. Viva Glam event for Saturday's World AIDS Day. Martin partnered with the cosmetics brand to raise awareness and funding for HIV/AIDS programs worldwide.

The "Livin' la Vida Loca" singer is developing a new series for NBC, expected in 2013. He's producing, writing and will star in the currently untitled dramedy, where he hopes to tackle social issues with humor.

He's also writing his second book and admitted he didn't have to look far for inspiration.

"I think it's time to write about things that I've been through with my kids that I'm sure many daddys out there will understand," said the father of 4-year-old twins Matteo and Valentino.

The family-friendly story about self-esteem is slated for release next summer.

___

AP writer Sigal Ratner-Arias contributed to this story.

___

Follow Nicole Evatt on Twitter at http://twitter.com/NicoleEvatt

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Unboxed: Stand-Up Desks Gaining Favor in the Workplace


THE health studies that conclude that people should sit less, and get up and move around more, have always struck me as fitting into the “well, duh” category.


But a closer look at the accumulating research on sitting reveals something more intriguing, and disturbing: the health hazards of sitting for long stretches are significant even for people who are quite active when they’re not sitting down. That point was reiterated recently in two studies, published in The British Journal of Sports Medicine and in Diabetologia, a journal of the European Association for the Study of Diabetes.


Suppose you stick to a five-times-a-week gym regimen, as I do, and have put in a lifetime of hard cardio exercise, and have a resting heart rate that’s a significant fraction below the norm. That doesn’t inoculate you, apparently, from the perils of sitting.


The research comes more from observing the health results of people’s behavior than from discovering the biological and genetic triggers that may be associated with extended sitting. Still, scientists have determined that after an hour or more of sitting, the production of enzymes that burn fat in the body declines by as much as 90 percent. Extended sitting, they add, slows the body’s metabolism of glucose and lowers the levels of good (HDL) cholesterol in the blood. Those are risk factors toward developing heart disease and Type 2 diabetes.


“The science is still evolving, but we believe that sitting is harmful in itself,” says Dr. Toni Yancey, a professor of health services at the University of California, Los Angeles.


Yet many of us still spend long hours each day sitting in front of a computer.


The good news is that when creative capitalism is working as it should, problems open the door to opportunity. New knowledge spreads, attitudes shift, consumer demand emerges and companies and entrepreneurs develop new products. That process is under way, addressing what might be called the sitting crisis. The results have been workstations that allow modern information workers to stand, even walk, while toiling at a keyboard.


Dr. Yancey goes further. She has a treadmill desk in the office and works on her recumbent bike at home.


If there is a movement toward ergonomic diversity and upright work in the information age, it will also be a return to the past. Today, the diligent worker tends to be defined as a person who puts in long hours crouched in front of a screen. But in the 19th and early 20th centuries, office workers, like clerks, accountants and managers, mostly stood. Sitting was slacking. And if you stand at work today, you join a distinguished lineage — Leonardo da Vinci, Ben Franklin, Winston Churchill, Vladimir Nabokov and, according to a recent profile in The New York Times, Philip Roth.


DR. JAMES A. LEVINE of the Mayo Clinic is a leading researcher in the field of inactivity studies. When he began his research 15 years ago, he says, it was seen as a novelty.


“But it’s totally mainstream now,” he says. “There’s been an explosion of research in this area, because the health care cost implications are so enormous.”


Steelcase, the big maker of office furniture, has seen a similar trend in the emerging marketplace for adjustable workstations, which allow workers to sit or stand during the day, and for workstations with a treadmill underneath for walking. (Its treadmill model was inspired by Dr. Levine, who built his own and shared his research with Steelcase.)


The company offered its first models of height-adjustable desks in 2004. In the last five years, sales of its lines of adjustable desks and the treadmill desk have surged fivefold, to more than $40 million. Its models for stand-up work range from about $1,600 to more than $4,000 for a desk that includes an actual treadmill. Corporate customers include Chevron, Intel, Allstate, Boeing, Apple and Google.


“It started out very small, but it’s not a niche market anymore,” says Allan Smith, vice president for product marketing at Steelcase.


The Steelcase offerings are the Mercedes-Benzes and Cadillacs of upright workstations, but there are plenty of Chevys as well, especially from small, entrepreneurial companies.


In 2009, Daniel Sharkey was laid off as a plant manager of a tool-and-die factory, after nearly 30 years with the company. A garage tinkerer, Mr. Sharkey had designed his own adjustable desk for standing. On a whim, he called it the kangaroo desk, because “it holds things, and goes up and down.” He says that when he lost his job, his wife, Kathy, told him, “People think that kangaroo thing is pretty neat.”


Today, Mr. Sharkey’s company, Ergo Desktop, employs 16 people at its 8,000-square-foot assembly factory in Celina, Ohio. Sales of its several models, priced from $260 to $600, have quadrupled in the last year, and it now ships tens of thousands of workstations a year.


Steve Bordley of Scottsdale, Ariz., also designed a solution for himself that became a full-time business. After a leg injury left him unable to run, he gained weight. So he fixed up a desktop that could be mounted on a treadmill he already owned. He walked slowly on the treadmill while making phone calls and working on a computer. In six weeks, Mr. Bordley says, he lost 25 pounds and his nagging back pain vanished.


He quit the commercial real estate business and founded TrekDesk in 2007. He began shipping his desk the next year. (The treadmill must be supplied by the user.) Sales have grown tenfold from 2008, with several thousand of the desks, priced at $479, now sold annually.


“It’s gone from being treated as a laughingstock to a product that many people find genuinely interesting,” Mr. Bordley says.


There is also a growing collection of do-it-yourself solutions for stand-up work. Many are posted on Web sites like howtogeek.com, and freely shared like recipes. For example, Colin Nederkoorn, chief executive of an e-mail marketing start-up, Customer.io, has posted one such design on his blog. Such setups can cost as little as $30 or even less, if cobbled together with available materials.


UPRIGHT workstations were hailed recently by no less a trend spotter of modern work habits and gadgetry than Wired magazine. In its October issue, it chose “Get a Standing Desk” as one of its “18 Data-Driven Ways to Be Happier, Healthier and Even a Little Smarter.”


The magazine has kept tabs on the evolving standing-desk research and marketplace, and several staff members have become converts themselves in the last few months.


“And we’re all universally happy about it,” Thomas Goetz, Wired’s executive editor, wrote in an e-mail — sent from his new standing desk.


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